Isaac Jackson managed several estates in northern Jamaica during the years of transition from slavery to free labor. Based in Hanover Parish, County of Cornwall, Jackson oversaw the interests of as many as a dozen estates engaged in the production of sugar and other crops, rum, and cattle during the 1830s and 1840s. Jackson's letterbooks contain approximately 825 letters pertaining to the daily management of Jamaican plantations. Beginning just a year after the end of apprenticeship, the mostly formulaic letters addressed to absentee British landowners, their attorneys, ship captains, and other estate managers touch on sugar and rum production and crop yields and cattle husbandry, but more importantly, they map out the course of the hard-edged negotiations between landowners and laborers as they struggled to shape the new labor regime.

Letters (including some transcripts and photostats) from and to Vaughan from many American and British correspondents, including: Also personal correspondence and business papers of Benjamin, Charles, Petty, Samuel Sr., Samuel Jr., William, William Oliver, and Sarah Vaughan (2 boxes); lectures, mostly in shorthand (3 vols.); a large number of notes and memoranda on a wide variety of topics, such as agriculture, architecture, astronomy, diplomacy, diseases, dueling, electricity, hieroglyphs, internal improvements, medicine, meteorology, land, manufactures, politics, punctuation, religion, silk-manufacturing, stock-breeding, taxation, Unitarianism, Benjamin Franklin, John Locke, Napoleon I, Joseph Priestley, Bowdoin College, town of Hallowell, Maine; notes on the peace negotiations, 1782-1783; miscellaneous legal papers; genealogy of the Abbott-Vaughan families. For a personal account of the collection, see Mrs. Mary Vaughan Marvin, "The Benjamin Vaughan Papers," APS Proceedings 95 (1951): 246-249.